EDCTP in 2019
The number of projects funded through the EDCTP2 programme jumped to 271 in 2019, supporting activities at more than 200 institutions in 37 countries in sub-Saharan Africa, as well as at 150 institutions in 16 countries in Europe.
New or improved medical interventions against
poverty-related infectious diseases.
Medical interventions
217
the total number of clinical studies supported by EDCTP2 since 2014. Of these, 59% (130) are interventional (clinical trials) and 41% (87) are non-interventional studies.
57%(71)
are phase II and III trials of drugs and vaccines which aim to deliver key evidence on safety and efficacy, as well as provide data to support product registration.
15%(18)
of the large-scale clinical studies involve post-licensing (phase IV) studies with a view to influencing health policies and practice and optimising the delivery of medical interventions for the wide-range of sub-Saharan African health systems and diverse populations.
10%(121)
of all studies target pregnant women and their children. Other key populations are also involved in the studies, such as newborns and infants (35; 17%), children (64; 31%) and adolescents (60; 29%).
32
Sub-Saharan Africa countries hosts recruitment sites of EDCTP-funded collaborative clinical studies.
Portfolio of grants by disease
Collaborative clinical trials and clinical studies
Capacity development
coordination
Partnerships
proposals
Ten new calls for proposals were launched in 2019 and awards were agreed for the 11 calls opened in 2018.
EDCTP2 has now developed an extensive portfolio, balanced across its focus disease areas:
84
collaborative clinical research grants
217
clinical studies in progress or planning stages
37
countries and 208 organisations in sub-Saharan Africa participating in EDCTP projects, alongside 16 countries and 150 institutions in Europes
27
countries in sub-Saharan Africa benefiting from ethics review and regulatory strengthening projects.
EDCTP2 is seeing substantial sums invested in the sub-Saharan Africa science base:
€526.04 M
invested in grant funding, 87% for large collaborative clinical trials
€1.06 BN
committed by European and African EDCTP Participating States Member States through cash and in-kind contributions
€323.90 M
likely to be leveraged through collaborative activities with third parties
57.6%
of EDCTP funding going to sub-Saharan Africa partners
EDCTP2 is also making important contributions to the development of human capital in the African region:
130
fellowship grants awarded (37.3% to women)
172
long-term trainees supported (including 85 PhDs) from 26 countries; 47% of trainees are women
318
clinical trials-related training courses organised for 7,488 participants
The EDCTP portfolio is well-balanced, with 63.1% of projects being focused on the three major poverty-related infectious diseases (HIV and HIV-associated infections, tuberculosis and malaria), 15.5% on neglected infectious diseases, 10.7% on emerging and re-emerging infections, and 10.7% on diarrhoeal diseases and lower respiratory tract infections.
Support is currently being provided for 217 clinical studies, 60% of them interventional trials. Most trials are phase II and III trials of drugs and vaccines (57.3%), although 11.3% are phase IV and implementation studies. Of key populations, pregnant and breastfeeding women are involved in 10% of studies, newborns and infants in 17%, children in 31% and adolescents in 29%.
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Towards EDCTP's objectives
2014-2019
Towards
EDCTP2’s
objectives
New or improved medical interventions against
poverty-related infectious diseases.
Medical interventions
217
the total number of clinical studies supported by EDCTP2 since 2014. Of these, 59% (130) are interventional (clinical trials) and 41% (87) are non-interventional studies.
57%(71)
are phase II and III trials of drugs and vaccines which aim to deliver key evidence on safety and efficacy, as well as provide data to support product registration.
15%(18)
of the large-scale clinical studies involve post-licensing (phase IV) studies with a view to influencing health policies and practice and optimising the delivery of medical interventions for the wide-range of sub-Saharan African health systems and diverse populations.
10%(121)
of all studies target pregnant women and their children. Other key populations are also involved in the studies, such as newborns and infants (35; 17%), children (64; 31%) and adolescents (60; 29%).
32
Sub-Saharan Africa countries hosts recruitment sites of EDCTP-funded collaborative clinical studies.
Increase cooperation
with sub-Saharan Africa through capacity building for conducting clinical trials according to ethical principles and regulatory standards
Collaboration and capacity development
37
sub-Saharan African countries participate in EDCTP projects involving 208 sub-Saharan African organisations. These account for 57.6% of total EDCTP funding.
27
sub-Saharan African countries have received EDCTP support for the establishment of functional regulatory systems and capacities for ethical review of clinical research.
€23.43 M
has been invested to support preparedness of 6 sub-Saharan African countries in the ght against Ebola
outbreaks.
89
fellowships that focus on the career development of researchers.
7,488
people have participated in EDCTP project-related training and workshops on topics such as study protocol development, specimen collection, research and administration, Good Clinical Practice and epidemic preparedness.
16
sub-Saharan African countries are members of the EDCTP Association. By end of 2019, these members have submitted 120 Participating States’ Initiated Activities (PSIAs) of total committed value of €67 million.
Improve coordination alignment and integration of
European National Programmes.
European coordination
14
European countries are members of the EDCTP Association.
€158.8 M
total cash received from the European Participating States to the EDCTP programme.
Increase international cooperation with public
and private partners.
External partnerships
16
sub-Saharan African countries are full members of the EDCTP Association. These members have contributed to a total of €1.21 million by end of 2018 through the Participating States’ Initiated Activities (PISIAs) – research activities within the scope of the EDCTP programme that are funded and implemented by one or more member countries.
60%
of the total EDCTP grant value is allocated to sub-Saharan African institutions (€186 million).
162
private sector entities are involved in EDCTP projects. By end of 2019, these organisations have received €89.26 million in grant value.
60%
of the total EDCTP grant value is allocated to sub-Saharan African institutions (€186 million).
Increase interaction with other EU initiatives, including those linked to development assistance.
External partnerships
68
private sector entities are involved in EDCTP projects. By end of 2018 , these organisations have received €49.42 M in grant value.
3
grant consortia were established through an EDCTP call to support health systems/service optimisation research capacities in cooperation with development assistant’. Two of these consortia received funding from international development cooperation
partners (SIDA and USAID).
17
EDCTP African member countries participated in a survey to inform the development of a strategic policy plan for strengthening health research systems capacities of countries in sub-Saharan Africa. This project is a joint initiative between EDCTP and WHO-AFRO.
Total funding
€447.04 M
In 192 projects awarded by end of 2018
EDCTP’s investment
in research & development
2003-2018
Portfolio of grants by disease
Note:
A further €58.01M for 153 grants was awarded to projects on non-disease-specific topics.
*EDCTP grants only
**EDCTP. grants only
By intervention
Note:
A further €110.47M for 246 grants was awarded to projects on non-intervention-specific topics.
*EDCTP grants only